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human tsp1  (R&D Systems)
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Human Tsp1, supplied by R&D Systems, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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recombinant tsp1  (R&D Systems)
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CD36 triggers blast migration. A, GO analysis of migration-related biological processes significantly enriched in the CD36 gene signature. B, Number of migrating shCtrl or shCD36 U937 cells in the lower chamber of the transwell assay (normalized to control; n = 5). C, As in B, but with CD36-blocking antibodies (FA6-152 or JC53.1; n = 4). D, Number of migrating cells in primary AML samples treated or not with CD36 blocking antibody (FA6-152; n = 7). E, Number of migrating shCtrl or shTSP1 U937 cells (normalized to control; n = 3). F, Number of migrating shCtrl or shCD36 U937 cells treated or not with <t>TSP1-blocking</t> antibody (A6.1; normalized to shCtrl; n = 5). G, Number of migrating U937 cells treated or not with <t>recombinant</t> TSP1 in the presence or not of CD36-blocking antibody (FA6-152; normalized to control; n = 3). H, As in D, but with TSP1-blocking antibody (A6.1; n = 5). I, Bioluminescence imaging of mice injected with the indicated AML cell line stably expressing a luciferase reporter from day 1 to day 64 after injection. J, Representative histologic section showing anti-human Ku-80 labeling of U937 AML blasts in the subcutaneous adipose tissue 17 days after xenograft. Positive brown nuclei highlight the infiltration of human blasts in murine adipose tissue either as dense infiltrate (top) or scattered isolated cells (bottom). Top scale bar, 50 μm; bottom, 10 μm. K, Percentage of viable OCIAML3 cells in the indicated tissues 14 days after orthotopic injection in the femur. L, Expression of CD36 [mean fluorescence intensity (MFI)] in viable OCIAML3 cells measured in the injected and contralateral femur and different organs of mice 14 days after orthotopic injection. Values are represented as mean ± SEM. B, C, and E, One sample t test. D and H, Paired t test. F and G, Ordinary one-way ANOVA with Tukey multiple comparisons test. L, Matched one-way ANOVA. *, P < 0.05; **, P < 0.01; ***, P < 0.001; ****, P < 0.0001; ns, not significant.
Recombinant Tsp1, supplied by R&D Systems, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/recombinant tsp1/product/R&D Systems
Average 95 stars, based on 1 article reviews
recombinant tsp1 - by Bioz Stars, 2026-03
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CD36 triggers blast migration. A, GO analysis of migration-related biological processes significantly enriched in the CD36 gene signature. B, Number of migrating shCtrl or shCD36 U937 cells in the lower chamber of the transwell assay (normalized to control; n = 5). C, As in B, but with CD36-blocking antibodies (FA6-152 or JC53.1; n = 4). D, Number of migrating cells in primary AML samples treated or not with CD36 blocking antibody (FA6-152; n = 7). E, Number of migrating shCtrl or shTSP1 U937 cells (normalized to control; n = 3). F, Number of migrating shCtrl or shCD36 U937 cells treated or not with <t>TSP1-blocking</t> antibody (A6.1; normalized to shCtrl; n = 5). G, Number of migrating U937 cells treated or not with <t>recombinant</t> TSP1 in the presence or not of CD36-blocking antibody (FA6-152; normalized to control; n = 3). H, As in D, but with TSP1-blocking antibody (A6.1; n = 5). I, Bioluminescence imaging of mice injected with the indicated AML cell line stably expressing a luciferase reporter from day 1 to day 64 after injection. J, Representative histologic section showing anti-human Ku-80 labeling of U937 AML blasts in the subcutaneous adipose tissue 17 days after xenograft. Positive brown nuclei highlight the infiltration of human blasts in murine adipose tissue either as dense infiltrate (top) or scattered isolated cells (bottom). Top scale bar, 50 μm; bottom, 10 μm. K, Percentage of viable OCIAML3 cells in the indicated tissues 14 days after orthotopic injection in the femur. L, Expression of CD36 [mean fluorescence intensity (MFI)] in viable OCIAML3 cells measured in the injected and contralateral femur and different organs of mice 14 days after orthotopic injection. Values are represented as mean ± SEM. B, C, and E, One sample t test. D and H, Paired t test. F and G, Ordinary one-way ANOVA with Tukey multiple comparisons test. L, Matched one-way ANOVA. *, P < 0.05; **, P < 0.01; ***, P < 0.001; ****, P < 0.0001; ns, not significant.
A2058 Recombinant Human Tsp1 R D Systems, supplied by R&D Systems, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/a2058 recombinant human tsp1 r d systems/product/R&D Systems
Average 95 stars, based on 1 article reviews
a2058 recombinant human tsp1 r d systems - by Bioz Stars, 2026-03
95/100 stars
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recombinant human tsp1  (R&D Systems)
95
R&D Systems recombinant human tsp1
CD36 triggers blast migration. A, GO analysis of migration-related biological processes significantly enriched in the CD36 gene signature. B, Number of migrating shCtrl or shCD36 U937 cells in the lower chamber of the transwell assay (normalized to control; n = 5). C, As in B, but with CD36-blocking antibodies (FA6-152 or JC53.1; n = 4). D, Number of migrating cells in primary AML samples treated or not with CD36 blocking antibody (FA6-152; n = 7). E, Number of migrating shCtrl or shTSP1 U937 cells (normalized to control; n = 3). F, Number of migrating shCtrl or shCD36 U937 cells treated or not with <t>TSP1-blocking</t> antibody (A6.1; normalized to shCtrl; n = 5). G, Number of migrating U937 cells treated or not with <t>recombinant</t> TSP1 in the presence or not of CD36-blocking antibody (FA6-152; normalized to control; n = 3). H, As in D, but with TSP1-blocking antibody (A6.1; n = 5). I, Bioluminescence imaging of mice injected with the indicated AML cell line stably expressing a luciferase reporter from day 1 to day 64 after injection. J, Representative histologic section showing anti-human Ku-80 labeling of U937 AML blasts in the subcutaneous adipose tissue 17 days after xenograft. Positive brown nuclei highlight the infiltration of human blasts in murine adipose tissue either as dense infiltrate (top) or scattered isolated cells (bottom). Top scale bar, 50 μm; bottom, 10 μm. K, Percentage of viable OCIAML3 cells in the indicated tissues 14 days after orthotopic injection in the femur. L, Expression of CD36 [mean fluorescence intensity (MFI)] in viable OCIAML3 cells measured in the injected and contralateral femur and different organs of mice 14 days after orthotopic injection. Values are represented as mean ± SEM. B, C, and E, One sample t test. D and H, Paired t test. F and G, Ordinary one-way ANOVA with Tukey multiple comparisons test. L, Matched one-way ANOVA. *, P < 0.05; **, P < 0.01; ***, P < 0.001; ****, P < 0.0001; ns, not significant.
Recombinant Human Tsp1, supplied by R&D Systems, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/recombinant human tsp1/product/R&D Systems
Average 95 stars, based on 1 article reviews
recombinant human tsp1 - by Bioz Stars, 2026-03
95/100 stars
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human recombinant tsp1  (R&D Systems)
94
R&D Systems human recombinant tsp1
CD36 triggers blast migration. A, GO analysis of migration-related biological processes significantly enriched in the CD36 gene signature. B, Number of migrating shCtrl or shCD36 U937 cells in the lower chamber of the transwell assay (normalized to control; n = 5). C, As in B, but with CD36-blocking antibodies (FA6-152 or JC53.1; n = 4). D, Number of migrating cells in primary AML samples treated or not with CD36 blocking antibody (FA6-152; n = 7). E, Number of migrating shCtrl or shTSP1 U937 cells (normalized to control; n = 3). F, Number of migrating shCtrl or shCD36 U937 cells treated or not with <t>TSP1-blocking</t> antibody (A6.1; normalized to shCtrl; n = 5). G, Number of migrating U937 cells treated or not with <t>recombinant</t> TSP1 in the presence or not of CD36-blocking antibody (FA6-152; normalized to control; n = 3). H, As in D, but with TSP1-blocking antibody (A6.1; n = 5). I, Bioluminescence imaging of mice injected with the indicated AML cell line stably expressing a luciferase reporter from day 1 to day 64 after injection. J, Representative histologic section showing anti-human Ku-80 labeling of U937 AML blasts in the subcutaneous adipose tissue 17 days after xenograft. Positive brown nuclei highlight the infiltration of human blasts in murine adipose tissue either as dense infiltrate (top) or scattered isolated cells (bottom). Top scale bar, 50 μm; bottom, 10 μm. K, Percentage of viable OCIAML3 cells in the indicated tissues 14 days after orthotopic injection in the femur. L, Expression of CD36 [mean fluorescence intensity (MFI)] in viable OCIAML3 cells measured in the injected and contralateral femur and different organs of mice 14 days after orthotopic injection. Values are represented as mean ± SEM. B, C, and E, One sample t test. D and H, Paired t test. F and G, Ordinary one-way ANOVA with Tukey multiple comparisons test. L, Matched one-way ANOVA. *, P < 0.05; **, P < 0.01; ***, P < 0.001; ****, P < 0.0001; ns, not significant.
Human Recombinant Tsp1, supplied by R&D Systems, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/human recombinant tsp1/product/R&D Systems
Average 94 stars, based on 1 article reviews
human recombinant tsp1 - by Bioz Stars, 2026-03
94/100 stars
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CD36 triggers blast migration. A, GO analysis of migration-related biological processes significantly enriched in the CD36 gene signature. B, Number of migrating shCtrl or shCD36 U937 cells in the lower chamber of the transwell assay (normalized to control; n = 5). C, As in B, but with CD36-blocking antibodies (FA6-152 or JC53.1; n = 4). D, Number of migrating cells in primary AML samples treated or not with CD36 blocking antibody (FA6-152; n = 7). E, Number of migrating shCtrl or shTSP1 U937 cells (normalized to control; n = 3). F, Number of migrating shCtrl or shCD36 U937 cells treated or not with TSP1-blocking antibody (A6.1; normalized to shCtrl; n = 5). G, Number of migrating U937 cells treated or not with recombinant TSP1 in the presence or not of CD36-blocking antibody (FA6-152; normalized to control; n = 3). H, As in D, but with TSP1-blocking antibody (A6.1; n = 5). I, Bioluminescence imaging of mice injected with the indicated AML cell line stably expressing a luciferase reporter from day 1 to day 64 after injection. J, Representative histologic section showing anti-human Ku-80 labeling of U937 AML blasts in the subcutaneous adipose tissue 17 days after xenograft. Positive brown nuclei highlight the infiltration of human blasts in murine adipose tissue either as dense infiltrate (top) or scattered isolated cells (bottom). Top scale bar, 50 μm; bottom, 10 μm. K, Percentage of viable OCIAML3 cells in the indicated tissues 14 days after orthotopic injection in the femur. L, Expression of CD36 [mean fluorescence intensity (MFI)] in viable OCIAML3 cells measured in the injected and contralateral femur and different organs of mice 14 days after orthotopic injection. Values are represented as mean ± SEM. B, C, and E, One sample t test. D and H, Paired t test. F and G, Ordinary one-way ANOVA with Tukey multiple comparisons test. L, Matched one-way ANOVA. *, P < 0.05; **, P < 0.01; ***, P < 0.001; ****, P < 0.0001; ns, not significant.

Journal: Cancer Research

Article Title: CD36 Drives Metastasis and Relapse in Acute Myeloid Leukemia

doi: 10.1158/0008-5472.CAN-22-3682

Figure Lengend Snippet: CD36 triggers blast migration. A, GO analysis of migration-related biological processes significantly enriched in the CD36 gene signature. B, Number of migrating shCtrl or shCD36 U937 cells in the lower chamber of the transwell assay (normalized to control; n = 5). C, As in B, but with CD36-blocking antibodies (FA6-152 or JC53.1; n = 4). D, Number of migrating cells in primary AML samples treated or not with CD36 blocking antibody (FA6-152; n = 7). E, Number of migrating shCtrl or shTSP1 U937 cells (normalized to control; n = 3). F, Number of migrating shCtrl or shCD36 U937 cells treated or not with TSP1-blocking antibody (A6.1; normalized to shCtrl; n = 5). G, Number of migrating U937 cells treated or not with recombinant TSP1 in the presence or not of CD36-blocking antibody (FA6-152; normalized to control; n = 3). H, As in D, but with TSP1-blocking antibody (A6.1; n = 5). I, Bioluminescence imaging of mice injected with the indicated AML cell line stably expressing a luciferase reporter from day 1 to day 64 after injection. J, Representative histologic section showing anti-human Ku-80 labeling of U937 AML blasts in the subcutaneous adipose tissue 17 days after xenograft. Positive brown nuclei highlight the infiltration of human blasts in murine adipose tissue either as dense infiltrate (top) or scattered isolated cells (bottom). Top scale bar, 50 μm; bottom, 10 μm. K, Percentage of viable OCIAML3 cells in the indicated tissues 14 days after orthotopic injection in the femur. L, Expression of CD36 [mean fluorescence intensity (MFI)] in viable OCIAML3 cells measured in the injected and contralateral femur and different organs of mice 14 days after orthotopic injection. Values are represented as mean ± SEM. B, C, and E, One sample t test. D and H, Paired t test. F and G, Ordinary one-way ANOVA with Tukey multiple comparisons test. L, Matched one-way ANOVA. *, P < 0.05; **, P < 0.01; ***, P < 0.001; ****, P < 0.0001; ns, not significant.

Article Snippet: As indicated, anti-CD36 blocking antibodies (1 μg/mL; FA6-152, Stem Cell Technologies 60084 or Cayman chemical JC63.1 10009893) and/or recombinant TSP1 (2 nmol/L; R&D Systems 3074-TH) were added in the upper chamber.

Techniques: Migration, Transwell Assay, Control, Blocking Assay, Recombinant, Imaging, Injection, Stable Transfection, Expressing, Luciferase, Labeling, Isolation, Fluorescence